To all the women who’ve heard the frustrating “it’s all in your head” in response to medical maladies, a new study out Friday feels your pain.

shows that women actually do experience exacerbated chronic pain compared to men — a gap that can be explained by biological differences in the immune system.

“The pain of women has been overlooked in clinical practice,” lead author Geoffroy Laumet said, “with the idea that it’s more in the mind, or that it’s because women are softer and more emotional.”