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October 27, 2026
 

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STEM CELLS

RiHeart, an iPS cell-based sheet, has been put into practical use for heart surgery after it was exhibited at the 2025 Osaka Expo.
JAPAN / FOCUS
Oct 20, 2026
Technologies seen at Osaka Expo increasingly being put into practice
Heart muscle cells, a “human washing machine” and a flying car have all seen new interest or progress since the event.
A lab-grown heart made from induced pluripotent stem cells in Osaka in April 2025
JAPAN / Science & Health
Sep 30, 2026
Heart muscle stem cells see first clinical use in surgery in Japan
Sheets of muscle cells derived from regenerative products known as iPS cells were transplanted into the heart of a patient in her 50s.
A cardiac muscle cell sheet that uses induced pluripotent stem cells
JAPAN / Science & Health
Jul 22, 2026
Another iPS product approved for public insurance coverage in Japan
It is the second case of insurance coverage approval in the nation for an induced pluripotent stem cell-derived regenerative medicine product.
Long-term safety has been confirmed after neural progenitor cells derived from iPS cells were transplanted into patients with spinal cord injuries, a team of researchers at Keio University has said.
JAPAN / Science & Health
Jul 21, 2026
Long-term safety of iPS spinal cord therapy confirmed in Japan
The team plans to launch an investigator-initiated clinical trial as early as next year to bring it into practical use.
A Japanese startup tested a catheter injection of iPS heart muscle cells on a patient at Shinshu University Hospital in late March.
JAPAN / Science & Health
Jun 13, 2026
Japan startup tests catheter injection of iPS heart muscle cells
The Tokyo-based company hopes to develop a minimally invasive treatment method that does not require surgery.
IPS cells cultured by Sumitomo Pharma
JAPAN / Science & Health
May 13, 2026
Health panel approves coverage for iPS cell-derived Parkinson’s disease treatment
The approval of Sumitomo Pharma’s Amchepry makes it the world’s first commercialized medical product derived from iPS cells.
A Japanese research team has developed miniaturized testicular tissues called testicular organoids from mouse embryonic stem cells, in a world first.
JAPAN / Science & Health
Feb 27, 2026
Japanese researchers create mouse testicular organoids in vitro
Two of the researchers were also the first to create ovarian organoids from mouse embryonic stem cells, in 2021.
An iPS cell-derived heart muscle sheet developed by Cuorips
JAPAN / Science & Health / FOCUS
Feb 20, 2026
iPS cell-based products win conditional approval from health ministry panel
The endorsement was based on small-scale clinical studies that confirmed only their safety and “presumed” their efficacy.
Myocardial sheets made from iPS cells
JAPAN
Feb 19, 2026
Japan panel OKs medical products using iPS cells
The products, if approved by the health minister, are expected to be the world’s first of their kind.
A clinical trial by a Tokyo-based venture company has confirmed that transplanting cardiac muscle cell clusters created from iPS cells into patients with severe heart failure improved their cardiac functions and symptoms.
JAPAN / Science & Health
Dec 13, 2025
Tokyo startup confirms efficacy of iPS cell-derived heart muscle transplants
According to Friday’s announcement, the transplant was performed on 10 patients, and no major safety issues were confirmed.
With concerns rising over babies whose genetic makeup has been altered to accommodate the parents' preferences, the government aims to submit related legislation during next year's ordinary parliamentary session at the earliest.
JAPAN
Dec 4, 2025
Japan eyes ban on gene-edited babies
The government aims to submit related legislation during next year’s ordinary parliamentary session at the earliest.
A Japanese research team comprising researchers from Kyoto University's Center for iPS Cell Research and Application and other institutions succeeded in producing iPS cells by adding artificially synthesized ribonucleic acid to human blood cells.
JAPAN / Science & Health
Dec 4, 2025
Japan team develops effective method to create iPS cells from blood
While a method to create iPS cells using skin cells and synthetic RNA has already been developed, it had been thought to be difficult to produce iPS cells from blood cells.
A research team from Kyoto University has announced that it is the first in the world to create 3D jawbone-like organoids from human induced pluripotent stem, or iPS, cells.
JAPAN / Science & Health
Aug 19, 2025
Kyoto University group successfully creates jawbone from iPS cells
The team expects that its method will be applied to regenerative medicine and drug discovery.
Sumitomo Pharma applied to Japanese regulators for manufacturing and marketing authorization aimed at treating patients with advanced Parkinson's disease.
JAPAN / Science & Health
Aug 5, 2025
Drugmaker in Japan seeks approval for stem cell treatment for Parkinson’s
A trial led by Kyoto University researchers indicated treatment using induced Pluripotent Stem cells was safe and successful in improving symptoms of the disease.
A regenerative medicine startup, Kyoto-based iHeart Japan, said Monday that it has conducted a clinical trial to transplant a treatment sheet containing cardiac muscle cells derived from human induced pluripotent stem cells into a patient with a heart muscle disease.
JAPAN / Science & Health
Jul 29, 2025
Japan startup transplants iPS cells for heart treatment in clinical trial
The layered sheet containing three types of cells and gelatin particles were placed on the surface of the heart, and are expected to improve the heart’s contractions.
A screenshot of a health ministry website shows an application form to submit documents for approval of a regenerative medicine program.
JAPAN / Science & Health
Jul 28, 2025
Health bureaus’ inconsistencies on regenerative medicine plans spark outcry
In one case, a regional health and welfare bureau immediately approved a regenerative medicine program but a different bureau rejected the same treatment plan.
By pioneering stem cell therapies, Japan is not only treating disease but also seeking to rejuvenate a nation grappling with aging and decline.
COMMENTARY / Japan
Jun 20, 2025
Japan is helping lead the way in regenerative medicine
In pristine labs across Japan, scientists are tinkering with the architecture of regeneration.
A Japanese team has started a final-stage clinical trial to administer to patients with familial Alzheimer's disease a drug discovered using iPS cells.
JAPAN / Science & Health
Jun 4, 2025
Japanese team starts final-stage trial for iPS drug to treat Alzheimer’s
Through the trial, which began in May, the team aims to confirm the safety and efficacy of the treatment, with hopes of obtaining regulatory approval.
Kyoto University's Center for iPS Cell Research and Application in Kyoto
JAPAN / Science & Health
Apr 23, 2025
Japan team treats chronic kidney disease with iPS cells in mice
The hope is such an achievement leads to the development of an effective therapy for chronic kidney disease.
A 3D rendering of multiple induced pluripotent stem cells
JAPAN
Apr 18, 2025
University of Osaka team develops miniature livers from iPS cells
The team expects the small livers can be used to treat patients with end-stage liver disease.
Two Japanese climbers die on remote Himalayan peak in Nepal
Rescuers have recovered the bodies of two Japanese climbers missing for over a week on a remote Himalayan mountain.
Aging Japanese village turns to Peru in search of new residents
Guests from Peru's Belen district interact with a baby in Nanmoku village in Gunma Prefecture.
Budget-friendly restaurant chain Saizeriya succumbs to rising costs
A Tokyo branch of Saizeriya, a chain of family-style Italian restaurants
U.S. has for years asked Musk to alter Starlink service in Ukraine and Middle East, sources say
A Ukrainian soldier sets up a Starlink satellite internet system near the frontline in the Donetsk region, Ukraine, on Oct. 16
U.S. military bans Chinese-made BYD cars from key air base in Okinawa
An F-22 Raptor lands at Kadena Air Base in Kadena, Okinawa Prefecture on Oct. 9. The base is a crucial hub for U.S. military operations in the region.
A dramatic bear hunt in a midsize Japanese city could be a harbinger of what is to come
Zookeeper Tetsuo Iso at the site of frantic search for a wild bear in Utsunomiya on June 9. Iso, 65, was asked by the prefectural government to help capture the bear and it was his shot with a tranquilizer gun that put an end to the saga.
How this long-term resident avoids the annoying tourist label in Japan
Tourists enjoy themselves while crossing the famous Shibuya Crossing in Tokyo on Oct. 12.
What can Asia do to avoid crossing crucial climate tipping points?
Motorists drive through a road covered with smog from wildfires nearby in Ogan Ilir in Indonesia's South Sumatra province on Sept. 25.
Baku championships showcase rising standards in global sumo
Ryan Roddy (second from left back) is pictured with the Ireland sumo team at this month's World Sumo Championships in Baku, Azerbaijan.
91AV原创 permanent residency reform has a glaring blind spot
Japan's immigration reforms risk creating uncertainty by tying permanent residency more closely to language proficiency before clear assessment standards and supporting infrastructure are in place.

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